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The National Institute of Diabetes and Kidney Diseases explains that nephrotic syndrome is a medical condition in which the kidneys do not function properly

Kalantar-Zadeh, K., Streja, E., Miller, J

doi: 10.1016/j.lfs.2013.01.001 47 KoehlerJAKainTDruckerDJ

Notice: Strictly for laboratory research use only

Thus, first, a drug should be influxed from the blood to the brain capillary endothelial cells via a luminal uptake transporter and subsequently effluxed to the brain ECF via an abluminal transporter

Altogether it can be concluded that an observed elevation of cobalamin in blood merits the a full diagnostic work up to assess the presence of disease