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SP has been found to contain multiple functional compounds including polysaccharides, proteins and lipids with potential anti-oxidant, anti-inflammatory and immunomodulatory effects 25 , making it a great candidate for handling the complicated pathology of RA

Studies demonstrate that during ferroptosis, ferroptotic cells release the autophagy-dependent DAMP high-mobility group box 1 (HMGB1)

AIF was proposed before the concept of ferroptosis, and it has been involved in the study of apoptosis

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