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Abstract Fitzcharles MA, et al

Diabetes Obes Metab 24:15531564 Son J, Accili D (2023) Reversing pancreatic beta-cell dedifferentiation in the treatment of type 2 diabetes

By reducing oxidative stress, systemic inflammation, and metabolic dysregulation, these agents may counteract key mechanisms involved in the development of DPN

Preclinical studies have consistently shown that targeting ferroptosis with drugs such as iron chelators, lipid peroxidation inhibitors or NRF2 activators can produce significant neuroprotective effects

In contrast to rAmy, Cagri primarily engages the CTR in a bypass conformation, equivalent to that observed when bound to AMYRs, with 85% of particles in the final particle stack stabilised in this conformation (Fig

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