Muscle tension from poor posture, arthritis, and osteoporosis are common sources of pain in this region
(Khavinsons team, who discovered these peptides, showed pinealocyte stimulation with the related peptide epithalon, but not pinealon) Huberman described pinealon as the only thing he has ever found that can improve REM sleep
It was noted that prolonged exposure of MC can lead from mild to severe dermal injuries
Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guilln N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA Jr, Clark CG, Embley TM, Barrell B, Fraser CM, and Hall N
PMID 16766527
The clinical evidence exists but is limited small trials, older studies, no large RCTs
