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Side effects included gastrointestinal disorders (including nausea and vomiting), which affected 10% of people who used Wegovy compared to 2% of people who used the placebo

Brain Sci

Understanding the established adverse effect profile of semaglutide provides essential context when evaluating new or unexpected symptoms during treatment, including musculoskeletal complaints such as lower back pain

DISCLOSURES Cindy Wassef, Radhika Shah, Mahin Alamgir, Samantha Ouellette, and Giulia Frias have no conflicts of interest to disclose

Reply from Regenics 2026.03.02 Thank you so much for taking the time to share your experience

An independent external adjudication committee (EAC) validated prespecified categories of adverse events (including deaths, selected cardiovascular events, malignant neoplasms, thyroid diseases [malignant thyroid neoplasms and C-cell hyperplasia], acute kidney injury, acute pancreatitis, and lactic acidosis) except in SUSTAIN 10 where there was no adjudication