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Nicotine caused significant inhibition in yields of the physiologically active metabolite 5-dihydrotestosterone (DHT) in HGF and HPF, overcome to varying degrees by the anti-oxidant glutathione (n = 6

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Ford JM, Hait WN, Matlin SA and Benz CC

This cascade leads to endothelial injury, glomerular hyperfiltration, and enhanced macromolecule permeability which causes inflammation and glomerulosclerosis

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