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Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney

368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption

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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

The GLP-1 Legacy sits within that wider picture as one practical aftercare tool