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Results Here we show that in vivo genome editing enables sustained Exendin-4 secretion from liver cells, leading to prolonged elevation of Exendin-4 levels in the bloodstream

Flow cytometry analysis of EpCAM + cells on the liver cell preparation before MACS and on the EpCAM neg fraction after MACS

PT-141 (bremelanotide) is a melanocortin receptor agonist that works in the brain it increases the signals that produce arousal in the first place

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Tesofensine is a triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine) extensively studied in pre-clinical models of appetite regulation, energy expenditure, and central reward pathways