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Headaches and fatigue are also possible

[55] It achieves glycemic control primarily through a glucose-dependent mechanism: by binding to GLP-1 receptors on beta cells, it elevates intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA) and related signaling pathways

The SURMOUNT-1 trial, also in the New England Journal of Medicine, studied tirzepatide in adults with obesity or overweight without type 2 diabetes

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Individual Case Reports: The Encouraging Stories Several detailed case reports have been published documenting individual pregnancy outcomes after GLP-1 exposure