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It works locally in the intestines as a guanylate cyclase-C agonist

References Orsini A, Bologna E, Bignante G, Lasorsa F, Lambertini L, Biasatti A, et al

This is clinically real and routinely missed, says Dr

Muller TD, Clemmensen C, Finan B, DiMarchi RD, Tschop MH

Short-chain fatty acids improve BBB integrity SCFAs are the most extensively studied microbial-derived metabolites with considerable influence on BBB integrity (Fig