The average adults daily requirement is estimated to be 2.4 micrograms a day, with the best dietary sources of B12 coming from animal products
Most adults reach a maintenance dose of around 1.0 to 2.4 mg per week via subcutaneous injection, ramping up slowly to limit nausea
for example, only 2030% of patients in the USA achieve the recommended glycemic control targets 4,5
It has a large volume of distribution, reflecting its extensive tissue penetration, and is metabolized through proteolytic cleavage by dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidase (NEP)
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Vomiting in particular was 30.9% with the pill, much higher than its injection counterpart