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An important exploratory outcome measured in the initial 41-day Phase 2a study was the effect of cotadutide treatment on liver fat reduction as measured by MRI, with a 39.12% reduction was observed in the treatment group compared to 19.51% in placebo group (83)

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If approved, the MHRA would assess the benefitrisk profile independently for the UK market, and NICE would subsequently evaluate cost-effectiveness before recommending NHS commissioning

Regulatory Approval and Market Demand The recognition of allulose's health benefits, such as low caloric content and minimal impact on blood glucose levels, has led to increased consumer demand for low-calorie sweeteners