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CAFs, in particular, are vital contributors to ECM remodeling, secreting collagen I and fibronectin that increase ECM stiffness and activate tumor-promoting signaling pathways, including the YAP/TAZ pathway

Research has documented effects on approximately 4,000 genes, with 59% being upregulated (turned up) and 41% being downregulated (turned down)

Many studies have revealed that BHBA induces BDNF expression when the supply of glucose is insufficient

doi:10.1016/j.scitotenv.2015.12.157 Baertschi SW, Alsante KM, Tnnesen HH (2010) A critical assessment of the ICH guideline on photostability testing of new drug substances and products (Q1B): recommendation for revision

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