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In DKD, high glucose levels and other metabolic abnormalities activate inflammasomes in TECs, which then cleave the proinflammatory cytokine pro-IL-1 into its mature form, IL-1

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Interaction of Factors Determining Calcium Dynamics in Interneurons Ultimately, dynamics of [Ca 2+ ] i in interneurons is determined by the interaction between multiple ligand-gated and voltage-gated sources of calcium influx described above as well as additional factors, such as calcium release from internal stores (e.g., Goldberg et al., 2003a

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