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Bifidobacteria are important immunomodulators that modulate immune responses through multiple pathways, enhancing gut barrier function by upregulating suppressive Foxp3+ Tregs and inhibiting immune responses triggered by Th2 and Th17 cells 89

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Biological Treatment: Role of IL-23 Inhibition Professor Stefano Piaserico Development of Psoriasis Treatments While historically psoriasis treatment predominantly consisted of sun exposure, treatment has advanced over the last 100 years with addition of FAE, methotrexate, retinoids, topical vitamin D, ciclosporin, and biologics

In addition to glycolysis and OXPHOS, CSCs also strongly depend on alternative nutrient sources, including glutamine and fatty acids, further complicating metabolic targeting