In this promising context, the likely availability in the near future of drugs for T2D at dosages equal to those used in obesity and with average weight reduction of 20% compared to baseline, such as tirzepatide 15 mg [77], oral semaglutide 50 mg [54], CagriSema 2.4/2.4 mg [82], will compellingly raise the issue of first-line treatment of patients with T2D, which should clearly be addressed to the fundamental pathogenetic moment of T2D, namely the increase in adiposity
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