Deficient EBV-specific B-and T-cell response in patients with chronic fatigue syndrome
The long-term consequences of untreated low brain folatedevelopmental regression, speech impairment, seizures, and neuroinflammationcan be more severe than the risks associated with folate therapy
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Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms
Sometimes they may present with dysphagia because of development of OAC or Barretts ulcer