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Targeting NRF2 with the triterpenoid cddo-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Uric acid is one of the most effective water-soluble antioxidants in the blood

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doi: 10.1038/s41598-022-04880-1 10 ChevalierRL

Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

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