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Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimers disease

The potential locked within the compounds currently on the category 2 list is enormous, but it can only be realized through proper clinical investigation

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Progress has also been made using small molecules that target the peroxisome proliferator-activated receptors (PPAR, PPAR and PPAR (PPAR//)), a family of nuclear-acting receptors, which upon activation, improve systemic glucose and lipid metabolism 10,11