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Wellbutrin lowers the seizure threshold, and the risk increases with higher doses, rapid dose escalation, or in patients with predisposing factors (eating disorders, head trauma, alcohol withdrawal, or concurrent use of other medications that lower seizure threshold)

Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 10 Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway Authors Civantos E, Bosch E, Ramirez E, Zhenyukh O, Egido J, Lorenzo O, Mas S Received 17 January 2017 Accepted for publication 22 March 2017 Published 7 June 2017 Volume 2017:10 Pages 207222 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Ming-Hui Zou Esther Civantos, 1,2 Enrique Bosch, 1 Elisa Ramirez, 1 Olha Zhenyukh, 1 Jess Egido, 1,2 Oscar Lorenzo, 1,2 Sebastin Mas 1,2 1 Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacin Jimnez Daz, Autonoma University, 2 CIBERDEM (Biomedical Research Centre in Diabetes and Associated Metabolic Disorders), Madrid, Spain Background: Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor used in type 2 diabetes therapy, has demonstrated protective effects in diabetic chronic kidney disease, in part due to its pleiotropic actions

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There are no clear indications that GLP-1 medications increase the risks associated with alcohol consumption, says Christian Hendershot, PhD, an addiction researcher at the University of Southern California Keck School of Medicine in Los Angeles, California, who led a clinical study testing semaglutides effects on alcohol use