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It not only has antioxidant effects but also increases NRF2 levels, clears peroxynitrite, inhibits Fe 2 transport, and binds to protein thiol groups [430]

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Imbernon M, Saponaro C, Helms HC, Duquenne M, Fernandois D, Deligia E, et al

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IGF-1 was reported to stimulate AMPK pathway through LKB1/ATM 41 , interestingly as shown in Fig