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Relative abundance of SLC25A39 and GCLM transcripts in HEK-293T cells treated with BSO (1 mM) for the indicated days using quantitative reverse transcription PCR (RT-qPCR), normalized to transcripts of B-ACTIN

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[DOI] [PubMed] [Google Scholar] 8.Mohammed S.A.D., Hanxing L., Fang L., Algradi A.M., Alradhi M., Safi M., et al

By binding with IGF-1, IGF-2, and insulin, IGF-1R activates downstream pathways including phosphoinositide 3 kinase (PI3K)/AKT and Ras/extracellular signal-regulated protein kinase (ERK) pathways, 1 two frequently activated pathways in colorectal cancer