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According to the lawsuit, the companies failed to adequately warn healthcare providers and patients about the potential risks associated with these drugs, despite evidence and reports of gastrointestinal issues dating back to 2010

however, the methods used to investigate such a relationship have been limited [16]

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Left untreated, it can lead to bowel perforation, sepsis, and death

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Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial