Synapse 70:479500 Acknowledgements The authors are thankful to the Deanship of Graduate Studies and Scientific Research at the University of Bisha for supporting this work through the Fast-Track Research Support Program. Ethics declarations Ethical Approval Not applicable
doi: 10.1126/scitranslmed.3007218 45 OduoriOSMuraoNShimomuraKTakahashiHZhangQDouHet al
Although ROS can promote IL-1 and IL-10 2,3,4 , its precise role remains debated, with recent work highlighting mitochondrial ATP as a driver of NLRP3-dependent IL-1 release 5,6
Reactive oxygen species as a signal in glucose-stimulated insulin secretion
Most importantly, Ive got my energy back
Initiation and titration should follow product-specific protocols: Ozempic: Begin with 0.25 mg weekly for 4 weeks, then increase to 0.5 mg weekly, with further titration to 1 mg and potentially 2 mg weekly as tolerated Wegovy: Begin with 0.25 mg weekly for 4 weeks, then increase monthly through 0.5 mg, 1 mg, 1.7 mg, to a maintenance dose of 2.4 mg weekly Rybelsus: Begin with 3 mg once daily for 30 days, then increase to 7 mg daily, with further titration to 14 mg daily as needed [7] [8] MS patients may benefit from slower titration schedules if gastrointestinal tolerability is problematic
