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There were several limitations of our work, the main one being that this was an in vitro study using human cell lines in 2D cell cultures

it means animal results are a starting point, not evidence that something works or is safe in people

While that potency can lead to faster results, it also comes with a more pronounced side effect profile, including things like flushing, nausea, and appetite suppression

C.Sanchez-CalvoB.ValderramaR.et al (2013)

Inactivity, overeating, and an unhealthy lifestyle can cause an expansion of the residual fat cells and an increase in normal body weight