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Dichotomization of the slope of the linear regression of HbA1c was used as a reduction in HbA1c, and strictly negative slope values were labelled as positive

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Sample type considerations Different biological matrices have different detection characteristics: Urine: Most common testing matrix, metabolites accumulate Blood/plasma: Shorter detection windows for most peptides Dried blood spots: Emerging method with good sensitivity Hair: Not commonly used for peptides but theoretically possible Most anti-doping testing uses urine

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