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Yes, oral semaglutide (Rybelsus) is clinically proven to be effective

Gillespie et al

Many of these benefits relate to weight loss, but studies are underway to understand how these medications might affect health through additional mechanisms

1,2 The dose-by-dose data from the published trials: TRIUMPH-4s 18.2% discontinuation rate at 12 mg is more than three times higher than TRANSCEND-T2D-1s 5.1% on the same dose

The most exciting prospect may be combination therapies