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A total of 158,310 patients met the eligibility criteria for the emulation of SUSTAIN-6 and 44,671 patients for the emulation of SURPASS-CVOT

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(3) Patient stratification: Leverage mechanistic differences between CHS and EHS to design tailored trialse.g., testing anti-pyroptotic/anti-necroptotic agents in EHS and anti-apoptotic/gut barrier protectants in CHS [60, 61]

Studies have shown that TMAO is an independent risk factor for the occurrence of malignant adverse cardiovascular events, but whether it is harmful or beneficial to patients with cardiovascular diseases with mild or no clinical manifestations remains controversial