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Based on the above studies, we can speculate that regulating the hypoxic microenvironment and its associated HIF-1 upstream and downstream gene expression, such as VEGF, RIG-I and JAK/STAT3/HIF signaling pathways, may effectively reduce vascular inflammation and mitochondrial calcification in DM patients

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Assessing glutathione levels can provide information about the body's antioxidant capacity and potential inflammation

Patient education : Patients need support as they work to understand their medical, dietary, and lifestyle choices

Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X

What to do about it: Monitor your blood pressure if you self-inject at home, especially if you have hypertension