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found that berberine dose-dependently induces insulin secretion in HIT-T15 cells and mouse islets [78]

Another study demonstrated that neomycin and polymyxin B can significantly lower hepatic lipid build-up by decreasing the translocation of endotoxin in a MASLD mouse model (192)

doi:10.1016/bs.pbr.2021.04.005

Research note: A 2025 literature and patent review catalogued BPC-157's multifunctional activity across gastrointestinal, musculoskeletal, neurological, and cardiovascular preclinical models

Similarly, sodium butyrate enemas (60 mL, 80 mM) failed to show superiority over placebo in improving clinical remission rates in distal ulcerative colitis (UC) [143]

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