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The beneficial effects of SFN on lipid metabolism and NAFLD through the activation of Nrf2 have been reviewed previously (Xu et al., 2019

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In addition, both AICAR and RSVa SIRT1 activatorhave demonstrated efficacy in promoting mitochondrial adaptation and biogenesis, thereby reducing TEC injury and renal fibrosis in preclinical studies (Morigi et al., 2015

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The earliest symptoms of vitamin A deficiency are night blindness

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