does bpc 157 work systemically People talk about BPC-157 like it's one thing. It isn't. Oral BPC-157 stays local. It survives digestion long enough to act on the GI mucosa, then clears before it reaches systemic circulation The Hidden Risks of BPC‑157:

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Gastrointestinal issues: Conditions such as Crohn's disease, celiac disease, and irritable bowel syndrome (IBS) can damage the digestive tract making it harder for the body to absorb nutrients, including B12

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Repeated injections increase the risk

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Cytoprotection: organoprotection by somatostatin