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The first Phase 3 trial to report results, TRIUMPH-4, was published on 11 December 2025

Charles Barkley may be watching his waistline as the new spokesman for Weight Watchers, but apparently hes not watching his words too closely

In a 2020 randomized trial, 24 weeks of supplementation with R-ALA in 81 overweight adults with a BMI of 25 kg/m 2 or higher and elevated plasma triglyceride levels resulted in significantly more weight loss than placebo, with a relative reduction in BMI of 0.8 kg/m 2

This finding is fascinating

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As expected, participants randomised to the GLP-1 RAs were more likely to develop GI adverse events than those treated with placebo across all four trials