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It is particularly common when treatment begins or when the dosage is increased

Senescent cells stop producing collagen, begin secreting enzymes that degrade existing collagen and elastin, and create a local inflammatory environment that accelerates surrounding tissue aging

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These can range from nausea and facial flushing to changes in appetite and increased blood pressure

This means that the man-made active ingredient semaglutide, tirzepatide, or liraglutide binds to the same receptors

Pharmacol Res 1991;23:241-6