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Consistent with their increased oxidative stress and altered iron homeostasis 50 , senescent cells are also primed for ferroptosis, upregulating GPX4 to avoid cell death

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Additional research has demonstrated that correcting vitamin D deficiency can, in itself, increase glutathione levels

As reference, we also measured the expression of spxB (encodes for the pyruvate oxidase) [32, 33] and sodA (encodes for a superoxide dismutase) [6] that increased their transcript levels in response to H 2 O 2 , as reported for aerobic conditions [5]