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In a landmark Phase 2 trial published in the New England Journal of Medicine, participants receiving the 12 mg dose experienced mean weight loss of 24.2% at 48 weeks, significantly exceeding results from earlier GLP-1 or dual-agonist therapies

Patients on orforglipron should be aware of gallstone symptoms (right upper quadrant pain, nausea after fatty meals) and report them promptly

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Biased agonism and polymorphic variation at the GLP-1 receptor: Implications for the development of personalised therapeutics