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A higher percentage of the active compound reaching systemic circulation, and often, a faster onset of action
Several lines of evidence support this conclusion: (1) In vitro studies demonstrated that DA both binds and signals via 2 -adrenergic receptors, albeit at lower affinities than NE 46,78,79,80
Besides genetic predisposition, the development of DPN is closely linked to diabetes control and the effectiveness of its treatment, particularly in the early years following diagnosis [16]
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Regular tests can catch early signs of these problems