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In addition to the direct impact on the proportion of gut bacteria, GLP-1RAs were found to upregulate tight junction proteins in the intestinal mucosa, which helps prevent the translocation of bacteria to the blood

For more exploration of the angiogenesis issue, see the article that we have published on potential complications of TB-500

10.1016/j.exger.2023.112165 187 RahmanK

On the outer mitochondrial membrane, CPTI (carnitine-palmitoyl transferase I) catalyzes the transfer of medium/long-chain fatty acids esterified to coenzyme A (CoA) to L-carnitine

Other contributing factors to poor focus associated with ADHD include: Stress and cortisol imbalances (HPA axis dysregulation) Sleep deprivation or irregular circadian rhythms that can interfere with energy, motivation, and concentration, and can increase fatigue Blood sugar instability, which can worsen anxiety, brain fog, or irritability Micronutrient deficiencies, especially in magnesium, zinc, and B vitamins For women, hormonal fluctuations, like declining estrogen in perimenopause, can also worsen executive dysfunction and emotional reactivity (learn more about ADHD and hormones here)

Noom and Hims physicians screen for these during their consultation process