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The pharmacological mechanisms of GLP-1 agonists operate independently of thyroid function, targeting appetite regulation and glucose metabolism rather than thyroid hormone synthesis or action

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to estimate insulin sensitivity in patients treated with placebo, TZP or semaglutide after 28 weeks of treatment, achieving a hyperinsulinemic, euglycemic clamp experiment, followed by a hyperglycemic clamp (216 mg/dL) to estimate insulin secretory responses

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This regulatory difference is important when considering Mounjaro vs Trulicity for weight management goals.