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however, some patients may still not achieve metabolic targets and efficacy remains considerably less than that seen with bariatric surgery

21 Remarkably, even in HF-free patients with morbid obesity, cardiac abnormalities can be seen that are consistent with left ventricular (LV) remodelling and dysfunction, including greater LV mass, LV diastolic dysfunction and elevated LV filling pressure

Issues with batch normalization using NIST (National Institute of Standards and Technology) samples as reference due to low levels of these ACs in NIST compared to NESDA samples led to exclusion of these measures according to our quality control criteria after batch correction

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