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On the other hand, majority of IGF-I actions are mediated through the union of IGF-I to its putative receptor, IGF-IR, a tyrosine kinase that is one of the most potent natural activators of Akt pathway, involving among others: mTOR, MAPK, GSK3, FOXO, HDM2, Grb2 and Shc systems, all of them closely related with cell survival, growth and proliferation[1517]

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Animal model and experimental protocol Male C57BL/6 mice (8 weeks old) weighing 25 0.5 g were obtained from the Jackson Laboratory (Bar Harbor, ME)

Diet and training: Peptides optimize the hormonal environment, but they don't replace the need for proper nutrition and exercise

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Int J Toxicology