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Current Evidence and Clinical Trial Findings Phase 2 data published in the NEJM (2023) showed dose-dependent body weight reductions with retatrutide over 48 weeks, with gastrointestinal side effects being the most commonly reported

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Hence, the popular fitness trainer wisdom about The more muscle you have, the more calories you burn, even at rest. Unless you strength-train and take other steps to counteract age-related muscle loss, you can expect to lose 4 to 6 pounds of muscle per decade