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There was also enrichment of APM-related pathways, apparently activated in the human cells but suppressed in Myc-CaP (Fig

Less dramatic reductions in HGPRT activity do cause hyperuricemia and gout due to the reduced salvage of hypoxanthine and guanine leading to increased uric acid production

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This risk is increased up to 6-7-fold, if insulin resistance is present [54]

We speculated that participants would react with a similar GFR dip to ARB and SGLT2i, as they both lower efferent glomerular pressures [4], however this was not confirmed

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