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Zllner, Tapper, et al., 2022) has shown one-to-one amplitude-ratio soft constraint between the GABA amplitude and the co-edited macromolecules at 3.0 ppm (1to1GABAsoft in Osprey) performs better for edited MRS regarding to modeling performance
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It is typically used to treat joint pain, arthritis, ligament and tendon injuries, post-surgical recovery, nerve problems, and digestive issues such as IBD or leaky gut
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Specifically, after excluding 11 potential outliers, higher prefrontal GABA levels remained significantly associated with reduced prefrontal CBF levels ( = 0.176, P = 0.032)