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A: Review articles emphasize optimizing selective NNMT inhibitors like 5Amino1MQ and exploring coadministration with NAD precursors for cardiometabolic disorders

Intriguingly, GLP1/GIP had limited efficacy in our PCOS model with more severe metabolic complications, i.e., PWA mice fed HFD, suggesting that in the presence of persistently elevated androgen levels, its beneficial effects might be dampened