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Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, et al

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Hormone specialists note that progesterone is often the first hormone to drop during perimenopause, which helps explain why estrogen dominance becomes so common at this stage of life

2017 No serious adverse effects at therapeutic doses up to 1000 g/kg for 90 days

Pregnancy and breastfeeding call for individualized caution, as with IV nutrients generally