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[17] In some cases, dose adjustment within the approved range (up to 15 mg weekly for both Mounjaro and Zepbound) may be appropriate, but this decision should be based on objective clinical parameters rather than subjective impressions alone

Gallstone formation occurs in roughly 10-15% of people undergoing rapid weight loss from any cause, including GLP-1 medications

Practically, this makes tirzepatide slightly less forgiving of missed or delayed doses

Although sarcopenia is commonly associated with aging, sarcopenic obesity can also affect younger adults undergoing weight management, underscoring the importance of sufficient protein intake [26]

Thats more than what weve seen with todays leading medications

Conclusions Ultimately, while further investigation will help clarify the risks and benefits of GLP-1 RAs with respect to diabetic retinopathy and vision-threatening complications, its clear that GLP-1 RAs confer proven mortality and cardiovascular benefit