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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus under the brand name Mounjaro and for chronic weight management as Zepbound
In healthy subjects, subcutaneous injections of GLP-2 elicit a dose-related decrease in CTX-1 (a bone resorption marker), which has sparked suggestions for the use of GLP-2 as a potential osteoporosis treatment [68]
Duvillard L, Florentin E, Lizard G, Petit JM, Galland F, Monier S, et al Cell surface expression of LDL receptor is decreased in type 2 diabetic patients and is normalized by insulin therapy Diabetes Care
GLP-1 receptor agonists have shown the ability to reduce neuroinflammation and oxidative stresswell-recognized contributors to Alzheimers diseaseand provide neurotrophic effects in animal models of Alzheimers, the authors write, while cautioning that this needs to be verified by further clinical trials
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