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Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

contraindications include peritonitis and mechanical gastrointestinal or urinary obstruction

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Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/ leptin dual agonist

Note: Dosage protocols are highly individualized