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In cartilage tissues of the OA knee, upregulation of inflammation-related proteins is accompanied by the downregulation of GLP-1R and PKA/CREB pathways

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For patients with a history of cardiovascular events without heart failure, metformin, SGLT2 inhibitors, or GLP-1 RAs are recommended as first-line and DPP4 inhibitors, pioglitazone, acarbose, or insulin as second-line treatment [5]

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